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KMID : 1007020100080010026
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Korean Soceity of Osteroporosis
2010 Volume.8 No. 1 p.26 ~ p.37
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Effects of Combined Estrogen and Effervescent Fluocalcic Therapy on the Bone Mineral Density and Bone Metabolism of Surgical Menopause Women with Osteopenia
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Choi Hoon
Jung Min-Hyung
Kong Eun-Hee
Kim Heung-Yeol
Joo Il-Woo
Lee Ji-Young
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Abstract
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Objective: To evaluate the effects of estrogen therapy and fluocalcic on the bone mineral density and bone metabolism in surgically menopausal osteopenic women.
Methods: This prospective randomized clinical trial examined the effects of conjugated equine estrogen and fluocalcic in combination and separately, on bone mass density (BMD) and biochemical markers of bone turnover in 200 women with low bone mass. Treatment included 1 mg estradiol (Group I, n=50), 2 mg estradiol (Group II, n=50), 1mg estradiol plus fluocalcic (Group III, n=50), and 2mg estradiol plus fluocalcic (Group IV, n=50) for 12 months. Bone density measurements were performed at 6 and 12 months at the lumbar spine and femur neck. Biochemical markers of bone turnover were also measured every 6 months.
Results: The BMD of the lumbar spine increased significantly during the treatment in Group III and Group IV (P<0.05), while the BMD of the femur neck increased slightly, but not significantly, during treatment in all groups. In addition, urinary deoxypyridinoline decreased significantly in Group III and Group IV at 12 months of treatment (P<0.005). On the other hand, serum osteocalcin and total alkaline phosphatase decreased slightly, but not significantly, in all groups during the treatment.
Conclusion: The combined treatment with estradiol and fluocalcic is more effective in surgically menopausal women with osteopenia because it decreases bone biochemical markers and increases BMD.
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KEYWORD
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Osteopenia, Estradiol, Fluocalcic
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